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The toxic effects and the course of TEC and ATEC poisoning, studied here in greater detail in the , resemble those of the citrate ion introduced into the circulation, resulting in deionization of calcium and the effects of hypocalcemia. . 283-298 (1959) Toxicology of the Citric Acid Esters: Tributyl Citrate, Acetyl Tributyl Citrate .
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Citrate chelates calcium (and magensium) (that is why it is used, to prevent clotting of store blood products) and this is the mechanism of citrate intoxication. Signs and symptoms of hypocalcemia (whether or not caused by citrate) include hypotension, decreased pulse pressure, arrhythmias, increased LVEDP and CVP, mental status changes, tetany .
Citrate Toxicity. In general, apheresis performed with citrate anticoagulation is considered safe, and serious side effects are uncommon. 17 However, as citrate containing blood is returned to the donor, chelation of cations can continue in the systemic circulation. Consequently, metabolic complications ensue (hypocalcemia, hypomagnesemia, metabolic alkalosis, and other electrolyte .
Acetyl tributyl citrate | C20H34O8 | CID 6505 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological .
Comments Off on Toxicity Profile for Acetyl tributyl citrate (2002) Acetyl tributyl citrate was not a skin irritant or sensitizer in volunteers. It showed moderate eye irritation in the rat but no skin irritation in rabbits or sensitization in guinea pigs.